Ieee transactions on biomedical circuits and systems 1 classde ultrasound transducer driver for hifu therapy carlos christoffersen, senior member, ieee, wai wong, member, ieee, samuel pichardo, member, ieee. The platform combines verasonics cutting edge vantage systems. Verasonics, a leader in research ultrasound, and sonic concepts, an innovator of highperformance transducers, collaborated to design and. They have a focal length of 75mm and combined with a focal area of less than 5mm 2 produce focal intensities in excess of 1700 wcm 2 at 1mhz and 600 wcm 2 at 0. With stateoftheart manufacturing capabilities and an experienced engineering team, we are able to provide your company with an ultrasonic transducer ideally suited for your application.
Hifuplex advanced focused ultrasound platform verasonics, a leader in research ultrasound, and sonic concepts, an innovator of highperformance transducers, collaborated to design and build the hifuplex. In clinical applications of hifu the transducer lies in degassed water and. Various clinical applications of high intensity focused ultrasound hifu have. Acoustic lens for capacitive micromachined ultrasonic. The integrated amplifier has been implemented with the ams ag h35 cmos. Piezo technologies provides semicustom, modular, and pure custom ultrasonic transducer products for high intensity focused ultrasound applications. Each of the hifu highintensity focused ultrasound ablation shots creates a cigarshaped lesion about 10 to 12 mm long, 3 mm wide, and 3 mm in diameter. Sonic concepts designs and produces topoftheline, cuttingedge. If you have a concept for an application of hifu, a device in development, or already a finished product that you think can be improved, transducerworks has the knowledge and capabilities to help design or redesign your transducer components.
The advanced cosmetic technology of the device can significantly tighten and lift several areas of the face, reduce the signs of aging and improve the tone of the skin in a single session, with. Since its release in 2012, ulthera ultherapy has been quickly growing in popularity with experts worldwide as an advanced hifu device for serious sagging, common treatment areas include. The hifu focus is near the water surface and the 2 mhz sound. These risks, resulting from the high power levels required for effective therapy, should be taken into account at the earliest stages in the design of a system.
Welcome to sonic concepts video series on high intensity focused ultrasound steering. Gbs hifu utherapy machine supply 7 different depths of transducers, each cartridge has different treatment functions. To ease a patients suffering during the long surgery time, it is desirable to produce the tissue necrosis as rapidly as possible. This transducer array will be used on a moveable probe by the surgeon to apply therapy. Real technology of hifu transducer hifu transmitter. A convenient, reliable, and fast acoustic pressure field. Piezocad is an excellent tool for rapid iterative transducer design optimization. Hifu transducers high intensity focussed ultrasound hifu is of considerable interest in both medical research and highpower applications. Highintensity focused ultrasound hifu beauty grace. Software piezocad is our piezoelectric transducer modeling software package that has been in use by companies, government laboratories, and universities around the world for more than 20 years. An oscillatory motion is generated at the focus of a 93element and 4. Design of hifu transducers to generate specific nonlinear. Transducer array beam profile and heating simulations we patterned the cmut membrane designs described above into a transducer array designed for noninvasive hifu ablation of liver tumors. Highintensity focused ultrasound hifu ucsf radiology.
The goal of this work was to determine transducer design parameters that produce either a specified shock amplitude in the focal waveform or specified peak. Sonic concepts h300 phased array hifu transducer is. This paper presents a practical implementation of an integrated mricompatible cmos amplifier capable of directly driving a piezoelectric ultrasound transducer suitable for highintensity focused ultrasound hifu therapy. Hifu uses precise and focused ultrasound energy to target the diseased cells of the prostate. Design of hifu transducers to generate specific nonlinear ultrasound fields uia 45 seattle, wa 6 april 2016 va khokhlova1,2, pv yuldashev2, pb rosnitskiy2, ad maxwell1, w kreider1, mr bailey1, oa sapozhnikov1,2 1 cimu, applied physics laboratory, university of washington, seattle, wa 2 limu, physics faculty, moscow state university, moscow, russia. Highintensity focused ultrasound hifu is a noninvasive therapeutic technique that uses nonionizing ultrasonic waves to heat tissue. The field of mriguided high intensity focused ultrasound surgery mrgfus is a rapidly evolving one with many potential applications in neurosurgery. Hifuplex advanced focused ultrasound platform verasonics. Array structure design for twodimensional highintensity.
The hifuplex portfolio is an ultrasoundguided, focused ultrasound usgfus platform designed to advance biomedical research. Hifu transducer high intensity focused ultrasound youtube. Hifu uses an ultrasound transducer, similar to the ones used for diagnostic imaging, but with much higher energy. The technology can be used to treat a range of disorders and as of 2015 is at various stages of development and commercialization. Design of hifu transducers to generate specific nonlinear ultrasound. Hifu heads for body and face lifting 7 different hifu.
Fem modeling was performed using ansys software package. Several hifu transducers of different design have been. Design of hifu transducers for generating specified nonlinear ultrasound fields abstract. The vantage software, along with the hifuplex, includes the following. A water tank, in which a 128element hifu spherical array is mounted in the bottom, and another 128element phased array imaging probe mounted in center of the transducer bowl. Applications that utilize nonlinear waves with developed shocks are of growing interest, for example, for mechanical disintegration as well as for accelerated thermal ablation oftissue. Pdf theoretical modeling and experimental study of high. When designing ultrasound transducers, there are 2 options for focusing the transducer signal.
The verasonics vantage 256 hifu system off screen drives both the hifu array and the imaging probe. With the developing of ultrasound technology and expending of its application. Hifu can be used to increase the flow of blood or lymph, or to destroy tissue, such as tumors, through a number of mechanisms. The vantage hifu technology enables both energy delivery and imaging using the same transmitters, for flexible and comprehensive exploration in ultrasoundguided hifu. Hifu application and the design is not small enough for a compact solution. Velocities reach their maximum values in the acoustic axis, and a whirlpool. Real technology of hifu transducer hifu transmitter hifu cartridge test operation video.
Us8727987b2 mechanical manipulator for hifu transducers. We also design and manufacture imaging transducers, hydrophones and generalpurpose ultrasound transducers. Better ultrasonic technologies 26 years of piezo and ultrasound transducer design, manufacture and marketing 17 years of medical hifu. It is also known as mrgfus mriguided focused ultrasound and fus focused ultrasound surgery. Hifu doesnt pass through solid bone or air, so its not suitable for every cancer. Verasonics vantage ultrasound systems are used today at numerous institutions and companies worldwide for fus research and product development. Various clinical applications of high intensity focused ultrasound hifu have different requirements on the pressure level and degree of nonlinear waveform distortion at the focus. Design and finite element simulation of an ultrasonic transducer of.
The velocity vector fields obtained by piv measurements for both hifu transducers tfc750 and tfc3000 for 20 w acoustic power measured by calorimetry are shown in fig. As above mentioned, a freely distributed hifu code was designed. Interferencefree ultrasound imaging during hifu therapy, using software tools. The tarray software package developed to analyze steering capabilities t array.
The company specializes in designing and manufacturing high intensity focused ultrasound hifu transducers, electronics and software. The sonic window a lowcost portable ultrasound system by fuller et al. High intensity focused ultrasound hifu is a wellknown technique to deposit large amounts of energy in a localized region without affecting intervening tissue31. Design considerations for hifu transducers tcs software. Beamforming for therapy with high intensity focused. High intensity focused ultrasound hifu cancer research uk. Pdf design of hifu transducers for generating specified. Precision acoustics ltd supplies a range of hifu transducers, all of which are designed for immersion use. Hifu is an innovative, noninvasive treatment for a wide range of tumors and diseases. Royal marsden nhs foundation trust, sutton, surrey, sm2 5pt, uk and 2deptartment of engineering science, institute of biomedical engineering, university of oxford, oxford ox1 3pj, uk.
This is the first of three articles on mrgfus, this paper focuses on the historical development of the technology and its potential applications to. In recent years, after the development of lowloss ceramics, its therapeutic value has been revisited because of. The 3 in 1 hifu highintensity focused ultrasound device is equipped with cutting edge technology that allows having more accurate sculpting of face and body and vagina tightening. Realtime monitoring of high intensity focused ultrasound. Therefore, converging the ultrasound emitted from the transducer to deliver with high power density is a perpetual goal for hifu. With the expanding applications of magnetic resonanceguided highintensity focused ultrasound mrhifu, there is an urgent need for a convenient, reliable, and fast acoustic pressure field measurement method to aid treatment protocol design, ensure consistent and safe operation of the transducer, and facilitate regulatory approval of new techniques. Highintensity focussed ultrasound hifu techniques make use of ultrasound transducers capable of delivering. Hifu transducers, high intensity focused ultrasound.
Harmonic motion imaging for focused ultrasound hmifu is a technique that can perform and monitor highintensity focused ultrasound hifu ablation. Lesions overlap to create a continuous zone of ablation. Part of this thesis has been published as the conference paper, \an integrated ultrasound transducer driver for hifu applications which was. The transducer alternates between highenergy power for ablation 3 s and lowenergy power for imaging 6 s. These devices are suitable for continuous wave or pulsed toneburst application and are highly. Various clinical applications of high intensity focused ultrasound hifu have different requirements for the pressure levels and degree of nonlinear waveform distortion at. Various clinical applications of high intensity focused ultrasound hifu have different requirements for the pressure levels and degree of nonlinear waveform distortion at the focus. He is a student member of the institute of electrical and electronics engineers ieee. The project takes many of the suggestions from the transducer design, electronics, and beamforming to be discussed later into account in the design of this lowcost, portable system. A base harness having two or three legs 12 is mounted on the treatment table. Design and fabrication of doublefocused ultrasound transducers. The ultrasonic sound waves heat and eliminate the cancer cells, keeping the healthy tissues of the prostate intact. High intensity focused ultrasound surgery hifu of the.
Design of hifu cmut arrays for treatment of liver and. Introduction hifu, or high intensity focused ultrasound, is a. Biis hifu transducers high intensity focused ultrasound consist of bowl aperture with focal point or cylindrical sector with focal line for physical, chemical, biological, thermal and highstress uses in nonlinear underwater acoustics. A mechanical manipulator 10 for controlling the movement of high intensity focused ultrasound hifu transducers, especially for medical use, such as in the treatment of cancers. The goal of this paper is to determine transducer design parameters that. Custom transducer design and manufacturing daxsonics. A userfriendly software package for hifu simulation request pdf.
Technological theoretical and numerical models of such transducers and the corresponding hifu fields are discussed. Transducers sonic concepts specializes in the development and manufacturing of high intensity focused ultrasound hifu transducers used in biomedical and industrial applications. A conical shape is visible in both cases, with the same global pattern as the distribution of the active bubbles observed in a previous study. Our optimized hifu transducer designs deliver large amounts of acoustic. High intensity focused ultrasound hifu high intensity focused ultrasound hifu is a treatment that aims to kill cancer cells with high frequency sound waves. Design of hifu transducers to generate specific nonlinear ultrasound fields. A central shaft mounted on the base harness carries a diagnostic probe as well as a plurality of treatment probes. Array structure design for twodimensional highintensity focused ultrasound transducer, piezo hannas. The goal of this paper is to determine transducer design parameters that produce either a specified shock amplitude in the focal waveform or specified peak pressures while still maintaining quasilinear. Whether its integrating hifu into an endoscope or catheter, developing a 7,000 element array around the human skull, or designing a hifu transducer to withstand 6,000 watts of peak power, sonic concepts can leverage its transducer design capabilities into your product. Various clinical applications of highintensity focused ultrasound have different requirements for the pressure levels and degree of nonlinear waveform distortion at the focus. Design of hifu transducers for generating specified nonlinear ultrasound fields.
Classde ultrasound transducer driver for hifu therapy. Highintensity focused ultrasound hifu lifts and tightens skin for a nonsurgical face lift and neck lift. Design of hifu transducers for generating specified. The finite element analysis software can calculate the transducer modal and. Using simulation to study ultrasound focusing for clinical. Robotic positioning system positions the hifu transducer with five degrees of freedom and high accuracy, covering a large treatment field curved tabletop with a selection of mattresses of different types and shapes support various patient positions hifu therapy transducer philips proprietary design, model sx140 focal length 140 mm.
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